About
Dr. Mishra is a Professor of Biomedical Sciences in the Department of Health and Life Sciences, with extensive expertise in biochemistry, microbiology, infectious diseases, and antimicrobial resistance. His research focuses on understanding the molecular mechanisms underlying bacterial pathogenesis, host-pathogen interactions, and the development of strategies to combat antibiotic resistance. His laboratory employs multidisciplinary approaches, including lipidomics, proteomics, genomics, and metabolomics, to investigate bacterial physiology and identify novel therapeutic targets.
Dr. Mishra’s principal research interests include antimicrobial resistance mechanisms; the interactions of mammalian platelet microbicidal proteins with bacterial pathogens; platelet-mediated antibacterial host defenses in vitro and in vivo; metabolic pathways as potential drug targets; antibiotic combination strategies to prevent the emergence of resistance; and the pathogenesis of endovascular infections. He has also made pioneering contributions to understanding the molecular mechanisms responsible for high-level daptomycin resistance in streptococci. These discoveries have advanced knowledge of bacterial adaptation, antimicrobial resistance, and the complex interactions between pathogens and host immune defenses.
Dr. Mishra is also deeply committed to teaching, mentorship, and academic development. Throughout his teaching and research career, he has mentored more than 50 undergraduate and graduate students, summer researchers, and research staff. His teaching portfolio encompasses General Microbiology, Parasitology, Biochemistry, and Cell and Molecular Biology at the undergraduate level, as well as Medical Biochemistry and Infectious Diseases at the graduate level. He has also contributed to the education and training of clinical and postdoctoral fellows through instruction in both clinical and non-clinical courses.