Nestor Gonzales-Cadavid, Ph.D.

Nestor Gonzales-Cadavid, Ph.D.

Professor of Medicine, Charles R. Drew University of Medicine and Science
DNA Repository and Molecular Medicine Core Leader

Charles R. Drew University of Medicine and Science
1731 E. 120th Street
Los Angeles, CA 90059

Phone: (323) 563-5959
Fax: (323) 563-9330
Email: ncadavid@ucla.edu

Education

Dr. Gonzalez-Cadavid is a Professor of Medicine at Charles R. Drew University of Medicine and Science and also Adj. Professor of Urology at the David Geffen School of Medicine at UCLA. Dr. Gonzales-Cadavid earned his M.Sc. degree in Biochemistry from the University of Buenos Aires, Argentina. He received his Ph.D. in Biochemistry from the University of Buenos Aires (Argentina) and London (England), and has been Professor at the Central University of Venezuela (Caracas, Venezuela) and visiting scientist at MIT (Boston, Ms), Caltech (Pasadena, CA), and UCLA (Los Angeles, CA), before joining the UCLA Department of Urology and later the Department of Internal Medicine at Charles R. Drew University.

Research Interests

Current research interests are focused on the role of myostatin and androgens on the maintenance of skeletal muscle mass and on myogenic differentiation, the application of constructs of nitric oxide synthase to gene therapy, and the role of nitric oxide and myostatin on myofibroblast differentiation in fibrosis.

Selected Publications

  1. Ferrini MG, Davila H, Valente EG, (Gonzalez-Cadavid NF*, Rajfer J*, *equal contributors) (2004) Aging-related induction of inducible nitric oxide synthase (iNOS) is vasculo-protective in the arterial media. Cardiovascular Res ;61:796-805.
  2. Qian A, Meals R, Rajfer J, Gonzalez-Cadavid NF (2004) Comparison of gene expression profiles between Peyronie's disease and Dupuytren's contracture. Urology, 64:399-404.
  3. Gonzalez-Cadavid NF, Bhasin S (2004) Role of myostatin in metabolism. Curr Opin Clin Nutr Metabol Care, 7:451-457.
  4. Gonzalez-Cadavid NF, Rajfer J (2004). Therapy of erectile function: Potential future treatments. Endocrine, 23:167-176.
  5. Gonzalez-Cadavid NF, Rajfer J (2004) Molecular and cellular aspects of the pathophysiology of Peyronie’s disease. Drug Discovery Today. Disease mechanisms, 1:99-106
  6. Davila HH, Magee TR, Rajfer J, Gonzalez-Cadavid NF (2004) Gene therapy with the inducible nitric oxide synthase (iNOS) cDNA regresses the fibrotic plaque in an animal model of Peyronie’s disease. Biol Reprod, 71:1568-1577
  7. Davila HH, Rajfer J, Gonzalez-Cadavid NF (2004) Corporal veno-occlusive dys function in the aging rat. evaluation by cavernosometry and cavernosography. Urology, 64:1261-1266.
  8. Gonzalez-Cadavid NF, Rajfer J (2004) Molecular pathophysiology and gene therapy of aging-related erectile dysfunction. Exptl Gerontol, 39:1705-1712
  9. Sinha-Hikim I, Taylor WE, Gonzalez-Cadavid NF, Zheng W, Bhasin S (2004) Androgen receptor in human skeletal muscle and cultured muscle satellite cells: Up-regulation by androgen treatment. J Clin Endocr Metabol 89:5245-5255.
  10. Davila H, Magee TR, Rajfer J, Gonzalez-Cadavid NF (2005). Peyronie's disease is associated with an increase of plasminogen activator inhibitor-1 (PAI-1) at the RNA and protein levels. Urology, 65(4):645-8.
  11. Jalkut M, Gonzalez-Cadavid N, Rajfer J (2004) New discoveries in the basic science understanding of Peyronie's disease. Curr Urol Rep 5:478-484.
  12. Jasuja R, Ramaraj P, Mac RP, Singh AB, Storer TW, Artaza J, Miller A, Singh R, Taylor WE, Lee ML, Davidson T, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S (2005) Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men. J Clin Endocrinol Metab 90:855-863.
  13. Artaza JN, Bhasin S, Magee TR, Porszasz Reisz S, Shen R, Groome NP, Fareez MM, Gonzalez-Cadavid NF (2005) Myostatin inhibits myogenesis and promotes adipogenesis in 10T1/2 mesenchymal multipotent cells. Endocrinology, 146: in press
  14. Singh R, Artaza JN, Taylor WE, Braga M, Gonzalez-Cadavid NF, Bhasin S (2005) Testosterone Inhibits Adipogenic Differentiation in 3T3-L1 cells: Possible Role of Androgen Receptor induced Nuclear Translocation of ?-catenin and activation of Wnt Signaling. Endocrinology, in press
  15. Vernet D, Qian A, Nolazco G, Cantini L, Magee TR, Ferrini MG, Rajfer J, Gonzalez-Cadavid NF (2005) Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells. Implications for Peyronie’s disease. Biol Reprod, preliminary acceptance
  16. Gonzalez-Cadavid NF, Rajfer J (2005) Inducible Nitric Oxide Synthase in erectile physiology. Current Pharmaceutical Design Molecular Biology of Sexual Dysfunction, ed by Seftel AD, in press
  17. Gonzalez-Cadavid NF, Rajfer J (2005) New insights on the cellular and molecular pathology of Peyronie’s disease.. Nature Urol, in press
  18. Magee TR, Ferrini MG, Gonzalez-Cadavid NF, Rajfer J (2005) The Future of Gene Therapy for the Treatment of Erectile Dysfunction. Contempor Urol, in press