Nestor Gonzales-Cadavid, Ph.D.
Professor of Medicine, Charles R. Drew University of Medicine and Science
DNA Repository and Molecular Medicine Core Leader
Charles R. Drew University of Medicine and Science
1731 E. 120th Street
Los Angeles, CA 90059
Phone: (323) 563-5959
Fax: (323) 563-9330
Gonzalez-Cadavid is a Professor of Medicine at Charles R. Drew
University of Medicine and Science and also Adj. Professor of Urology
at the David Geffen School of Medicine at UCLA. Dr. Gonzales-Cadavid
earned his M.Sc. degree in Biochemistry from the University of Buenos
Aires, Argentina. He received his Ph.D. in Biochemistry from the
University of Buenos Aires (Argentina) and London (England), and has
been Professor at the Central University of Venezuela (Caracas,
Venezuela) and visiting scientist at MIT (Boston, Ms), Caltech
(Pasadena, CA), and UCLA (Los Angeles, CA), before joining the UCLA
Department of Urology and later the Department of Internal Medicine at
Charles R. Drew University.
research interests are focused on the role of myostatin and androgens
on the maintenance of skeletal muscle mass and on myogenic
differentiation, the application of constructs of nitric oxide synthase
to gene therapy, and the role of nitric oxide and myostatin on
myofibroblast differentiation in fibrosis.
MG, Davila H, Valente EG, (Gonzalez-Cadavid NF*, Rajfer J*, *equal
contributors) (2004) Aging-related induction of inducible nitric oxide
synthase (iNOS) is vasculo-protective in the arterial media.
Cardiovascular Res ;61:796-805.
A, Meals R, Rajfer J, Gonzalez-Cadavid NF (2004) Comparison of gene
expression profiles between Peyronie's disease and Dupuytren's
contracture. Urology, 64:399-404.
- Gonzalez-Cadavid NF, Bhasin S (2004) Role of myostatin in metabolism. Curr Opin Clin Nutr Metabol Care, 7:451-457.
- Gonzalez-Cadavid NF, Rajfer J (2004). Therapy of erectile function: Potential future treatments. Endocrine, 23:167-176.
NF, Rajfer J (2004) Molecular and cellular aspects of the
pathophysiology of Peyronie’s disease. Drug Discovery Today. Disease
- Davila HH, Magee
TR, Rajfer J, Gonzalez-Cadavid NF (2004) Gene therapy with the
inducible nitric oxide synthase (iNOS) cDNA regresses the fibrotic
plaque in an animal model of Peyronie’s disease. Biol Reprod,
- Davila HH, Rajfer J, Gonzalez-Cadavid NF (2004) Corporal veno-occlusive dys
function in the aging rat. evaluation by cavernosometry and cavernosography. Urology, 64:1261-1266.
NF, Rajfer J (2004) Molecular pathophysiology and gene therapy of
aging-related erectile dysfunction. Exptl Gerontol, 39:1705-1712
Sinha-Hikim I, Taylor WE, Gonzalez-Cadavid NF, Zheng W, Bhasin S (2004)
Androgen receptor in human skeletal muscle and cultured muscle
satellite cells: Up-regulation by androgen treatment. J Clin Endocr
- Davila H, Magee
TR, Rajfer J, Gonzalez-Cadavid NF (2005). Peyronie's disease is
associated with an increase of plasminogen activator inhibitor-1
(PAI-1) at the RNA and protein levels. Urology, 65(4):645-8.
M, Gonzalez-Cadavid N, Rajfer J (2004) New discoveries in the basic
science understanding of Peyronie's disease. Curr Urol Rep 5:478-484.
R, Ramaraj P, Mac RP, Singh AB, Storer TW, Artaza J, Miller A, Singh R,
Taylor WE, Lee ML, Davidson T, Sinha-Hikim I, Gonzalez-Cadavid N,
Bhasin S (2005) Delta-4-androstene-3,17-dione binds androgen receptor,
promotes myogenesis in vitro, and increases serum testosterone levels,
fat-free mass, and muscle strength in hypogonadal men. J Clin
Endocrinol Metab 90:855-863.
- Artaza JN,
Bhasin S, Magee TR, Porszasz Reisz S, Shen R, Groome NP, Fareez MM,
Gonzalez-Cadavid NF (2005) Myostatin inhibits myogenesis and promotes
adipogenesis in 10T1/2 mesenchymal multipotent cells. Endocrinology,
146: in press
- Singh R, Artaza JN,
Taylor WE, Braga M, Gonzalez-Cadavid NF, Bhasin S (2005) Testosterone
Inhibits Adipogenic Differentiation in 3T3-L1 cells: Possible Role of
Androgen Receptor induced Nuclear Translocation of ?-catenin and
activation of Wnt Signaling. Endocrinology, in press
D, Qian A, Nolazco G, Cantini L, Magee TR, Ferrini MG, Rajfer J,
Gonzalez-Cadavid NF (2005) Evidence that osteogenic progenitor cells in
the human tunica albuginea may originate from stem cells. Implications
for Peyronie’s disease. Biol Reprod, preliminary acceptance
NF, Rajfer J (2005) Inducible Nitric Oxide Synthase in erectile
physiology. Current Pharmaceutical Design Molecular Biology of Sexual
Dysfunction, ed by Seftel AD, in press
NF, Rajfer J (2005) New insights on the cellular and molecular
pathology of Peyronie’s disease.. Nature Urol, in press
TR, Ferrini MG, Gonzalez-Cadavid NF, Rajfer J (2005) The Future of Gene
Therapy for the Treatment of Erectile Dysfunction. Contempor Urol, in