Division of Cancer Research and Training

Division of Cancer Research and Training

Overview

OUR MISSION

In 2002, the Department of Internal Medicine at CDU established a formal Division of Cancer Research and Training under the leadership of Dr. Jay Vadgama. Our mission is to design and conduct basic, clinical, applied, translational, and prevention research programs directed toward reducing cancer incidence, morbidity, and mortality in the underserved and minority communities which face cancer health disparities in Service Planning Area (SPA) 6 region of Los Angeles.

RESEARCH

research projects and pilots in partnership with UCLA which are aimed at addressing health disparities in the areas of Breast, Colon, Prostate, and Gynecological Cancers to name a few. Two additional Resources – Clinical Research Resource and Recruitment Resource aim to diversity patient and researcher recruitment into cancer health disparities research activities.
THE OBJECTIVES OF THE CENTER ARE AS FOLLOWS:

  • Objective 1: To provide infrastructure support to facilitate cancer research opportunities within CDU.
  • Objective 2: To provide a rich training and formalized mentoring environment for the next generation of cancer investigators.
  • Objective 3: To develop a collaborative program focused on culturally and linguistically appropriate community outreach, cancer education, and dissemination of evidence-based information.

PRIORITIES OBJECTIVES OF THE PARTNERSHIP 
The CDU/UCLA Cancer Center Partnership identified the following priorities within the categories of research, training, and outreach.

  • Priority 1: Increase the number and quality of cancer research projects at CDU by supporting full and pilot projects and increase the number of cancer researchers at CDU.
  • Priority 2: Enhance research capability of the CDU Tissue and Data Resources.
  • Priority 3: Create institutional capacity at CDU for performing cancer-related clinical trials by leveraging the community and existing clinical research facilities and resources.
  • Priority 4: Expose undergraduate and medical students, fellows, and faculty to cancer research training and encourage them to pursue or advance their careers in this area, and implement a formalized mentorship program whereby junior research investigators are counseled and mentored during their career development process.
  • Priority 5: Bring culturally and linguistically appropriate cancer research information to the community and increase community capacity to develop and implement culturally appropriate health prevention strategies through community-partnered participatory research. 

Examples of Types of Research Projects Supported by the Partnership:


Title

Research Type

Cancer Type

  • The transcription factor SLUG may drive the progression of Akt and HER2/neu overexpressing breast tumors

Basic/Clinical

Breast

  • Role of Alcohol in Breast Cancer

Basic

Breast

  • Identification of genes uniquely associated with trastuzumab resistance and tumor metastases in HER2 overexpressing breast cancer

Basic/Clinical

Breast

  • Targeting Nup 153 in Mammary Cancer Stem Cells

Basic

Breast

  • Tumor-Associated Macrophages, Arginase and Triple Negative Breast Cancer

Basic

Breast

  • Enhanced chemoprevention by phytochemicals in combination

Basic/Clinical

Prostate

  • STAT3 in Breast Cancer

Basic

Breast

  • Breast Cancer and HPV: Induced Genomic Instability Cellular Sequelae.

Basic

Breast

  • Obesity, Biomarkers, and Breast Cancer

Basic/Clinical

Breast

  • ICTBP's Digitial Biorepository Database for Colorectal Cancer - BMAP Initiative

Clinical

Colorectal

  • Smoking Cessation Survey for High Risk African-American Men

Outreach

All Cancer

  • Present Your Body - Health Perception in the Faith Community

Outreach

All Cancer

  • Latino Colorectal Cancer Screening Awareness Project

Outreach

Colorectal

  • Role CCN Proteins in Breast Cancer

Basic/Clinical

Breast

  • Biologic Factors in Triple Negative Breast Cancer

Basic/Clinical

Breast

  • Ancestral Differences in Prostate Stem/Progenitor Cell Abundance and Activity in Prostate Cancer

Basic/Clinical

Prostate

  • Evaluating and Targeting EMP2 in Triple Negative Breast Cancer

Basic/Clinical

Breast

  • Treating endometrial cancer by restoring signaling defects in the endometrial stem cell niche

Basic/Clinical

Gynecologic

  • Transitioning Underserved Breast Cancer Survivors to Primary Care: Reducing Disparities in Long-term Care

Outreach

All Cancer

  • Community Needs Assessment for Patient Navigation for Cancer Detection, Treatment and Control

Outreach

All Cancer

  • Community Partnership in Capacity Building: Training Promotores to Conduct Focus Groups with Mixtec Farm Workers

Outreach

All Cancer

  • Vitamin D and Vitamin D Receptor: Role of Expression Levels and Polymorphisms in breast and colorectal cancer

Basic/Clinical

Breast
Colorectal

  • Role of IGF1, IGFIR, and IGFBP signaling and clinical implications in breast and colorectal cancers.

Basic/Clinical

Breast
Colorectal

  • Effect of IGF1 Axis Polymorphisms in Breast Cancer Risk and Outcome

Basic/Clinical

Breast