RCMI Clinical Center for Research Excellence - Center for Urban Research Excellence in Diabetes & Metabolism
The specific aims for the Center of Urban Research and Education in Diabetes and Metabolism (CUREDM) are:
- To increase the critical mass of diabetes and metabolic-related clinical researchers;
- To promote faculty development through the support of mentored-research pilot projects by pairing dedicated senior investigators with promising junior faculty;
- To enhance the careers of junior investigators (JI) by providing an environment that facilitates scientific discovery and short-term curricula and/or formal degree training at Charles Drew University;
- To improve diabetes and metabolic disorder patient outcomes in the context of methodologically rigorous clinical research through two innovative research cores: 1) The Translational Research Core, which will collaborate with CDU’s research-intensive partner, UCLA; and 2) the Body Composition and Metabolism Core; and
- To increase the body of knowledge and research activity (grant submissions and procurement, presentations, and publications), especially in diabetes and metabolic disorders as they relate to improving the health care of women, ethnic/racial minorities, and other disadvantaged populations
ADMINISTRATIVE AND DEVELOPMENT CORE
This core is responsible for the day-to-day operations and provides oversight and implementation of key activities such as procurement, finances, personnel, fiscal planning, budgeting, strategic planning, faculty recruitment, scientific direction, evaluation, and program planning. This core’s development arm provides mentoring, financial, and scientific support for three meritorious research projects during the first year. In Years Two through Five, an additional project conducted by a newly recruited promising JI will be supported. Dr. Davidson, a leader in diabetes investigations, is the center's director. Additionally, the director works with three committees: 1) internal steering committee, 2) the RCMI external advisory committee, and 3) an external scientific advisory committee.
TRANSLATIONAL RESEARCH CORE
This Core provides biobehavioral and related qualitative research services in support of clinical research, particularly diabetes-related studies. It provides methodologies to examine the effectiveness, feasibility, and sustainability of established interventions in research studies in real-life settings. It serves as a centralized resource to enhance, expand, and support existing secondary database and health services related research. Researchers in this core support and provide technical assistance to promising JIs with clinical research projects. Additionally, the core addresses differences obtained in well-controlled research settings and community practice and disseminate clinical research.
BODY COMPOSITION AND METABOLISM CORE
This core provides metabolic and nutritional services in support of diabetes related research studies as well as provide centralized access to facilities and equipment for body composition assessment in humans; 2) enhance research capabilities and competitiveness of CDUinvestigators currently engaged in metabolic research; and 3) facilitate recruitment of investigators with expertise in state-of-the-art metabolic and body composition methodology.
Three developmental projects were chosen; they all aspire to eliminate diabetes or metabolic-related diseases in disadvantaged communities. Each promising JI has a faculty appointment at CDU, and none have external peer-reviewed research project grants or program project grants. Each promising JI is expected to receive R01 or similar funding for his/her independent research.
Pilot Project #1
(PI Diana Echeverry, M.D.): "The Effects of Pharmacologic Treatment of Depression on Glycated Hemoglobin, Lipids and Quality of Life in Underserved Hispanics and African Americans with Diabetes: A Randomized, Placebo Controlled Trial"
Pilot Project #2 (PI Stanley H. Hsia, M.D.): “Dose-Response Effects of Aerobic Exercise on Insulin Sensitivity and the Metabolic Syndrome”
Pilot Project #3 (PI Naureen Tareen, M.D.): “Early Nephropathy Study in Diabetes with Inhibitory Renin-Angiotensin-Aldosterone System Therapy (END-IT)”
In addition to those four JIs, the center provides support for two emerging scientists, Karen Herbst, M.D., Ph.D., and David Martins, M.D. Emerging scientists have sufficient experience in a certain area of research and are qualified to serve as the “teacher’s assistants” for the resource cores. They will provide technical support to less experience junior investigators.