Space:
Laboratory: Dr. Liu and Dr. Nishitani share a laboratory in Hawkins Building, Room 3033 at Charles Drew University of Medicine & Science. The 1500 sq. ft. laboratory space is used for molecular biology studies and includes a tissue culture and a chemical hood. Dr. Liu will also be establishing a BSL-3 facility in Room 3095, which will contain a class B biosafety hood to perform HIV-related work by the Liu lab personnel. An additional 250 sq. ft. of BSL3 space inside Room 3095 will function separately as the "clean room" for PCR sample preparation.
Grants:
Liu, Xuan D.D.S., Ph.D.
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Active
1 K23 DE00430-3, P.I.-Xuan Liu
NIH/NIDCR
Isolation of Genes Required for HPV-Mediated Oral cancer
9/1/1999 - 8/31/2004
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The long-term objective of this project is designed to investigate the differential expression of genes related in tumor cell transformation after HPV infection and exposure to tobacco-related carcinogens. The project studies the gene alteration in HPV-16 immortalized human oral keratinocytes (HOK-16B) and derived tumorigenic human oral keratinocytes (HOK-16B-BaP-T). The hypothesis being evaluated is that HPV-16 immortalized oral keratinocytes will convert to cancer cell when further exposed to tobacco-related chemical carcinogens and during this transformation process the genes expression pattern will be changed.
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Overlap (summarized for each individual):
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None
Active
1 R21 AA131353-01
NIH/NIAAA (P.I. - Xuan Liu)
Alcohol Mediated HIV-1 Infectivity in T-Lymphocytes
9/07/2000-8/31/2004
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The long-term objective of this project is to define the mechanism for alcohol mediated signal enhancement of HIV-1 infectivity in the quiescent T lymphocytes. The project studies are to examine the effects of alcohol on the HIV-1 infectivity to quiescent T lymphocytes. The hypothesis is that in addition to alcohol-induced impairment of immune function, alcohol may enhance HIV infectivity in the quiescent T lymphocytes through the alteration of the chemokine receptor expression.
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None
Active
1 R01 AA13562-01 (P.I. - Xuan Liu)
NIH/NIAAA
Alcohol Modulated HIV-1 Replication in Latent CD4+ Cells
10/01/2001-8/31/2006
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The object of this study is to examine the role of alcohol as a cofactor in the reactivation of viral replication in latent CD4+ T-lymphocytes. The hypothesis is that alcohol/ -CD3 co-stimulation optimizes productive viral replication in these cells.
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None
Active
3 U54 RR14616-04S1 (Center P.I.-Norris, Keith/Project P.I.-Xuan Liu)
NIH - RCMI/NCRR
Center of Excellence in Clinical Research/ Mechanism of HIV Infection in the Oral Mucosa (Subproject)
10/01/2001-8/31/2003
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The long-term objective is to investigate the mechanism of HIV infection in the oral mucosa. The project studies are to quantification of HIV infection in the oral epithelial, to identification and characterization of oral HIV strain, and to examine the effect of risk factors associated with HIV infection in oral route. The hypothesis is that in vivo, oral mucosa is infected by lymphoid cells and serves as a reservoir for ongoing reinfection.
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Overlap (summarized for each individual)
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None |
